Born and raised in Hong Kong, Lee is the champion of the 8th World Harmonica Festival in 2017 and the founder of the Hong Kong Harmonica Academy.
Lee's mentors include Franz Chmel, Sigmund Groven and the two-time Grammy Award Winner Howard Levy. He also studied under Sheng master Cheng Tak-wai.
He has performed at Carnegie Hall in New York, MuTh Concert Hall in Vienna, the Esplanade in Singapore and at the International Harmonica Festival in Seoul. He has performed with the Hong Kong Philharmonic Orchestra, the City Chamber Orchestra of Hong Kong, Hong Kong Chinese Orchestra, the Asian Youth Orchestra and the renowned classical music comedy duo Igudesman & Joo.
In addition, Lee has collaborated with various pop singers, namely, Eason Chan, Jacky Cheung, Hins Cheung, Alan Tam, Hacken Lee and Leon Lai. In 2018, his CD Gordon Lee and his Encore Trio was released.